Prognostic value of serum stimulating thyroglobulin in metastatic radioactive iodine refractory differentiated thyroid cancer

Purpose: To investigate the prognostic value of serum-stimulated thyroglobulin (ps-Tg) before first 131I therapy in patients with metastatic radioactive iodine-refractory differentiated thyroid cancer (RR-DTC). Methods: From August 2017 to 2020, clinical data for 160 papillary carcinoma (PTC) who received thyroidectomy and treatment were analyzed retrospectively. Differences related indices compared. Univariate multivariate logistic regression analyses used analyze factors affecting occurrence RR-DTC. Receiver-operator characteristic (ROC) curves determine discriminative power ps-Tg predicting RR-DTC, while Kaplan-Meier survival curve RR-DTC was drawn. Results: A total enrolled, including 47 males, 113 females (70.62 %). Overall mean age 39 ± 13 years old. The follow-up results showed that 68 refractory iodine. group higher than iodine-receptive (p < 0.001). Multivariate an independent risk factor (OR = 1.086, p 0.000). optimal cut-off progression 19.21 μg/L. iodine (≥ μg/L) μg/L Conclusion: independently predicts when is greater increase. This finding will be helpful order best time start make individualized decisions.